Dental infections and serum inflammatory markers in patients with and without severe heart disease
Identifieur interne : 008121 ( Main/Exploration ); précédent : 008120; suivant : 008122Dental infections and serum inflammatory markers in patients with and without severe heart disease
Auteurs : Jukka H. Meurman [Finlande, États-Unis] ; Sok-Ja Janket ; Markku Qvamström ; Pekka NuutinenSource :
- Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics [ 1079-2104 ] ; 2003.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Anticorps antibactériens (sang), Bouche édentée (), Chlamydia (immunologie), Femelle, Fibrinogène (analyse), Gingivite (), Helicobacter pylori (immunologie), Humains, Intervalles de confiance, Maladie coronarienne (), Maladie coronarienne (sang), Maladies des dents (), Maladies des dents (sang), Maladies parodontales (), Maladies parodontales (sang), Marqueurs biologiques (sang), Mâle, Médiateurs de l'inflammation (sang), Odds ratio, Poche parodontale (), Protéine C-réactive (analyse), Sédimentation du sang, Études cas-témoins, Études transversales.
- MESH :
- analyse : Fibrinogène, Protéine C-réactive.
- immunologie : Chlamydia, Helicobacter pylori.
- sang : Anticorps antibactériens, Maladie coronarienne, Maladies des dents, Maladies parodontales, Marqueurs biologiques, Médiateurs de l'inflammation.
- Pascal (Inist)
- Adulte d'âge moyen, Bouche édentée, Femelle, Gingivite, Humains, Infection, Cardiopathie, Dent, Intervalles de confiance, Maladie coronarienne, Maladies des dents, Maladies parodontales, Mâle, Odds ratio, Poche parodontale, Sédimentation du sang, Sérum, Marqueur biologique, Homme, Grave, Études cas-témoins, Études transversales.
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Antibodies, Bacterial (blood), Biological marker, Biomarkers (blood), Blood Sedimentation, C-Reactive Protein (analysis), Case-Control Studies, Chlamydia (immunology), Confidence Intervals, Coronary Disease (blood), Coronary Disease (complications), Cross-Sectional Studies, Female, Fibrinogen (analysis), Gingivitis (complications), Heart disease, Helicobacter pylori (immunology), Human, Humans, Infection, Inflammation Mediators (blood), Male, Middle Aged, Mouth, Edentulous (complications), Odds Ratio, Periodontal Diseases (blood), Periodontal Diseases (complications), Periodontal Pocket (complications), Serum, Severe, Tooth, Tooth Diseases (blood), Tooth Diseases (complications).
- MESH :
- chemical , analysis : C-Reactive Protein, Fibrinogen.
- chemical , blood : Antibodies, Bacterial, Biomarkers, Inflammation Mediators.
- blood : Coronary Disease, Periodontal Diseases, Tooth Diseases.
- complications : Coronary Disease, Gingivitis, Mouth, Edentulous, Periodontal Diseases, Periodontal Pocket, Tooth Diseases.
- immunology : Chlamydia, Helicobacter pylori.
- Blood Sedimentation, Case-Control Studies, Confidence Intervals, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Odds Ratio.
Abstract
Objective. The objective of this study was to investigate if patients with severe heart disease (CHD patients) present more signs of dental infections than patients without heart disease (non-CHD patients), if serum inflammatory markers differ between the groups, and if there is a link between these and the oral health parameters. Methods. We performed clinical and radiologic dental examinations and collected serum samples of 256 patients with New York Heart Association class II-IV heart disease (CHD patients) and 250 non-CHD controls. Serum samples were analysed using pertinent methods in the clinical laboratory of the hospital, and the differences in serum biomarkers between CHD patients and non-CHD patients were examined using various statistical methods. A modified dental index (MDI) was constructed and used in the analyses. Results. CHD patients were significantly more likely to be edentulous (34.8% vs. 14.8%) and retain less natural teeth than non-CHD patients (8.6 vs. 17) (P <.001). In CHD patients the remaining teeth and supporting tissues were more often diseased. High MDI scores were significantly associated with CHD status (OR 1.31, Cl 1.16-1.48), as was gingivitis (OR 3.37, Cl 1.66-6.86), while the presence of deep periodontal pockets was not. Serum C-reactive protein and fibrinogen concentrations and blood erythrocyte sedimentation rates were higher in the CHD group. Also, H. pylori and Chlamydia antibodies were significantly higher in the CHD group. Conclusion. CHD patients presented with poorer oral health status than non-CHD patients. Serum inflammatory markers were significantly higher in the CHD patients compared to the non-CHD group. High MDI scores linked with risk of CHD.
Affiliations:
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Le document en format XML
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Meurman</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>University of Helsinki, Helsinki University Central Hospital</s1><s3>FIN</s3></inist:fA14><country>Finlande</country><wicri:noRegion>University of Helsinki, Helsinki University Central Hospital</wicri:noRegion><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Harvard School of Public Health</s1><s3>USA</s3></inist:fA14><country>États-Unis</country><wicri:noRegion>Harvard School of Public Health</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Kuopio University Hospital</s1><s3>FIN</s3></inist:fA14><country>Finlande</country><wicri:noRegion>Kuopio University Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Janket, Sok Ja" sort="Janket, Sok Ja" uniqKey="Janket S" first="Sok-Ja" last="Janket">Sok-Ja Janket</name></author><author><name sortKey="Qvamstrom, Markku" sort="Qvamstrom, Markku" uniqKey="Qvamstrom M" first="Markku" last="Qvamström">Markku Qvamström</name></author><author><name sortKey="Nuutinen, Pekka" sort="Nuutinen, Pekka" uniqKey="Nuutinen P" first="Pekka" last="Nuutinen">Pekka Nuutinen</name></author></analytic><series><title level="j" type="main">Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics</title><title level="j" type="abbreviated">Oral surg. oral med. oral pathol. oral radiol. endo.</title><idno type="ISSN">1079-2104</idno><imprint><date when="2003">2003</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics</title><title level="j" type="abbreviated">Oral surg. oral med. oral pathol. oral radiol. endo.</title><idno type="ISSN">1079-2104</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibodies, Bacterial (blood)</term><term>Biological marker</term><term>Biomarkers (blood)</term><term>Blood Sedimentation</term><term>C-Reactive Protein (analysis)</term><term>Case-Control Studies</term><term>Chlamydia (immunology)</term><term>Confidence Intervals</term><term>Coronary Disease (blood)</term><term>Coronary Disease (complications)</term><term>Cross-Sectional Studies</term><term>Female</term><term>Fibrinogen (analysis)</term><term>Gingivitis (complications)</term><term>Heart disease</term><term>Helicobacter pylori (immunology)</term><term>Human</term><term>Humans</term><term>Infection</term><term>Inflammation Mediators (blood)</term><term>Male</term><term>Middle Aged</term><term>Mouth, Edentulous (complications)</term><term>Odds Ratio</term><term>Periodontal Diseases (blood)</term><term>Periodontal Diseases (complications)</term><term>Periodontal Pocket (complications)</term><term>Serum</term><term>Severe</term><term>Tooth</term><term>Tooth Diseases (blood)</term><term>Tooth Diseases (complications)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Anticorps antibactériens (sang)</term><term>Bouche édentée ()</term><term>Chlamydia (immunologie)</term><term>Femelle</term><term>Fibrinogène (analyse)</term><term>Gingivite ()</term><term>Helicobacter pylori (immunologie)</term><term>Humains</term><term>Intervalles de confiance</term><term>Maladie coronarienne ()</term><term>Maladie coronarienne (sang)</term><term>Maladies des dents ()</term><term>Maladies des dents (sang)</term><term>Maladies parodontales ()</term><term>Maladies parodontales (sang)</term><term>Marqueurs biologiques (sang)</term><term>Mâle</term><term>Médiateurs de l'inflammation (sang)</term><term>Odds ratio</term><term>Poche parodontale ()</term><term>Protéine C-réactive (analyse)</term><term>Sédimentation du sang</term><term>Études cas-témoins</term><term>Études transversales</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>C-Reactive Protein</term><term>Fibrinogen</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Bacterial</term><term>Biomarkers</term><term>Inflammation Mediators</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Fibrinogène</term><term>Protéine C-réactive</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Coronary Disease</term><term>Periodontal Diseases</term><term>Tooth Diseases</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Coronary Disease</term><term>Gingivitis</term><term>Mouth, Edentulous</term><term>Periodontal Diseases</term><term>Periodontal Pocket</term><term>Tooth Diseases</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Chlamydia</term><term>Helicobacter pylori</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Chlamydia</term><term>Helicobacter pylori</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antibactériens</term><term>Maladie coronarienne</term><term>Maladies des dents</term><term>Maladies parodontales</term><term>Marqueurs biologiques</term><term>Médiateurs de l'inflammation</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Blood Sedimentation</term><term>Case-Control Studies</term><term>Confidence Intervals</term><term>Cross-Sectional Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Odds Ratio</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Bouche édentée</term><term>Femelle</term><term>Gingivite</term><term>Humains</term><term>Infection</term><term>Cardiopathie</term><term>Dent</term><term>Intervalles de confiance</term><term>Maladie coronarienne</term><term>Maladies des dents</term><term>Maladies parodontales</term><term>Mâle</term><term>Odds ratio</term><term>Poche parodontale</term><term>Sédimentation du sang</term><term>Sérum</term><term>Marqueur biologique</term><term>Homme</term><term>Grave</term><term>Études cas-témoins</term><term>Études transversales</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective. The objective of this study was to investigate if patients with severe heart disease (CHD patients) present more signs of dental infections than patients without heart disease (non-CHD patients), if serum inflammatory markers differ between the groups, and if there is a link between these and the oral health parameters. Methods. We performed clinical and radiologic dental examinations and collected serum samples of 256 patients with New York Heart Association class II-IV heart disease (CHD patients) and 250 non-CHD controls. Serum samples were analysed using pertinent methods in the clinical laboratory of the hospital, and the differences in serum biomarkers between CHD patients and non-CHD patients were examined using various statistical methods. A modified dental index (MDI) was constructed and used in the analyses. Results. CHD patients were significantly more likely to be edentulous (34.8% vs. 14.8%) and retain less natural teeth than non-CHD patients (8.6 vs. 17) (P <.001). In CHD patients the remaining teeth and supporting tissues were more often diseased. High MDI scores were significantly associated with CHD status (OR 1.31, Cl 1.16-1.48), as was gingivitis (OR 3.37, Cl 1.66-6.86), while the presence of deep periodontal pockets was not. Serum C-reactive protein and fibrinogen concentrations and blood erythrocyte sedimentation rates were higher in the CHD group. Also, H. pylori and Chlamydia antibodies were significantly higher in the CHD group. Conclusion. CHD patients presented with poorer oral health status than non-CHD patients. Serum inflammatory markers were significantly higher in the CHD patients compared to the non-CHD group. High MDI scores linked with risk of CHD.</div></front></TEI><affiliations><list><country><li>Finlande</li><li>États-Unis</li></country><region><li>Uusimaa</li></region><settlement><li>Helsinki</li></settlement><orgName><li>Université d'Helsinki</li></orgName></list><tree><noCountry><name sortKey="Janket, Sok Ja" sort="Janket, Sok Ja" uniqKey="Janket S" first="Sok-Ja" last="Janket">Sok-Ja Janket</name><name sortKey="Nuutinen, Pekka" sort="Nuutinen, Pekka" uniqKey="Nuutinen P" first="Pekka" last="Nuutinen">Pekka Nuutinen</name><name sortKey="Qvamstrom, Markku" sort="Qvamstrom, Markku" uniqKey="Qvamstrom M" first="Markku" last="Qvamström">Markku Qvamström</name></noCountry><country name="Finlande"><region name="Uusimaa"><name sortKey="Meurman, Jukka H" sort="Meurman, Jukka H" uniqKey="Meurman J" first="Jukka H." last="Meurman">Jukka H. Meurman</name></region><name sortKey="Meurman, Jukka H" sort="Meurman, Jukka H" uniqKey="Meurman J" first="Jukka H." last="Meurman">Jukka H. Meurman</name></country><country name="États-Unis"><noRegion><name sortKey="Meurman, Jukka H" sort="Meurman, Jukka H" uniqKey="Meurman J" first="Jukka H." last="Meurman">Jukka H. Meurman</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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